Hydrochloric Acid → HCID 136342249, compound

Participants

Reaction Conditions

Reaction Steps

Keto-enol 7 (2.12 g, 5.93 mmol) was added to 100 mL of a 0.5 M solution of sodium methoxide in methanol and the mixture was stirred at 0° C. for 3 hours. A 1.0 M solution of hydrochloric acid (53 mL) was poured onto the reaction and the mixture was concentrated to less than half its volume under reduced pressure. The obtained slurry was stirred for 30 min at room temperature and then filtrated. The precipitate was washed with 20 mL of water and 20 mL of methanol, subsequently. The crude product was precipitated from acetone to give 13 as a yellow solid (1.70 g, 93%). mp: 280° C.;

Provenance & Evidence