HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 447728Generated: October 29, 2026
Diisopropylethylamine → HCID 135882282, compound
https://huagongshe.com/reaction/447728
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 67104078 | HCID 67104078 | — |
| Reactant | 2-(3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid | HCID 136174646 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 135882282 | HCID 135882282 | — |
Reaction Steps
A vial was charged with 2-(3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid (55 mg, 0.226 mmol), HBTU (125 mg, 0.33 mmol), 1-(4-Chloro-3-methyl-phenyl)-piperazine dihydrochloride (142 mg, 0.50 mmol), anhydrous DMF (2.0 mL), and DIPEA (0.5 mL). The vial was capped, heated to 45° C., and stirred overnight. The following day, the volatiles were removed in vacuo and separation by preparative hplc (reverse phase, acetonitrile-water gradient) gave 1-[4-(4-Chloro-3-methyl-phenyl)-piperazin-1-yl]-2-[3-(1H-imidazol-2-yl)-pyrazolo[3,4-b]pyridin-1-yl]-ethanone: MS (ES) [M+H]+ found: 436.4
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08481545B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-ba7fe3d1b2674e1dbe36d7725df93a5d |
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| Source note | uspto-grants-2013_07 |
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