HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphosgene → 1-Fluoro-3-iodo-2-isocyanato-5-methylbenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | 2-Fluoro-6-iodo-4-methylaniline | HCID 10977900 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-Fluoro-3-iodo-2-isocyanato-5-methylbenzene | HCID 86618940 | — |
Reaction Steps
A mixture of 2-fluoro-6-iodo-4-methylaniline (D1) (370 mg, 1.5 mmol), triphosgene (150 mg, 0.05 mmol), and dioxan (3 ml) was heated at reflux for 1 h 15 min then cooled and evaporated to give the crude title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481566B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-ecf9d9e7e55c4c8db6ec118133f1d105 |
| Source note | uspto-grants-2013_07 |