反应详情

A mixture of the crude 1-fluoro-3-iodo-2-isocyanato-5-methylbenzene from description D2, 4-amino-1-N-Boc piperidine (200 mg, 1 mmol), and dichloromethane (3 ml) was stirred at room temperature for 1 h then directly purified by chromatography on silica gel eluting with 0 to 10% methanol in dichloromethane. Further purification by MDAP (mass-directed auto-purification) gave the title compound 300 mg.

1. customthen directly purified by chromatography on silica gel eluting with 0 to 10% methanol in dichloromethane
2. customFurther purification
3. customby MDAP (mass-directed auto-purification)