HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,1-Dimethylethyl 4-(6-chloro-4-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinecarboxylate | HCID 59683276 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | 6-Chloro-4-fluoro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one hydrochloride | HCID 68624326 | — |
Reaction Steps
1,1-Dimethylethyl 4-(6-chloro-4-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinecarboxylate (D8) (0.203 mmol, 75 mg) and HCl (233 microliters of a 4M solution in 1,4-dioxane) were mixed together and stirred at room temperature for two hours. Solvent was evaporated to afford the title compound, mono hydrochloride salt, complete conversion, M++H=270.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481566B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-e1a6ed1c5b1a4e2c89fea7ef0110184e |
| Source note | uspto-grants-2013_07 |