Sodium Hydroxide → HCID 57515536, compound

HRID 44777Notes

Reaction equation

HRID 44777 reaction equation
Cl.Cl.[NH2:3][C:4]1[C:13]2[N:14]=[C:15]([CH3:25])[N:16]([CH2:17][C:18]3([OH:24])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[C:12]=2[C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=1.[OH-].[Na+]>>[NH2:3][C:4]1[C:13]2[N:14]=[C:15]([CH3:25])[N:16]([CH2:17][C:18]3([OH:24])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[C:12]=2[C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 57515537HCID 57515537, compound

Product 1

HCID 57515536HCID 57515536, compoundYield 77.1%

Procedure

A mixture of 4-[(4-amino-2-methyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)methyl]piperidin-4-ol dihydrochloride (0.80 g) and 1N sodium hydroxide (8 mL) was sonicated for 2 minutes. A solid was isolated by filtration, washed with water, and dried under high vacuum at 100° C. to provide 0.50 g of 4-[(4-amino-2-methyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)methyl]piperidin-4-ol as a yellow powder, mp>260.0° C. Anal. Calcd for C16H20N6O C, 61.52; H, 6.45; N, 26.90. Found: C, 61.23; H, 6.39; N, 26.92.

Workup

  1. customwas sonicated for 2 minutes
  2. customA solid was isolated by filtration
  3. washwashed with water
  4. customdried under high vacuum at 100° C.

Sources & evidence

ORD record
ord-28b718f3869c451681b2b9428319342a
Source dataset
uspto-grants-2013_09
Patent number
US08541438B2

Reaction notes

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