反应详情

温度

50 °C

To a suspension of 2-cyano-2-(3,4-dichloro-5-oxo-2,5-dihydrofuran-2-yl)acetamide (1.0 g) in methanol (10 ml) was added a solution of 1-[3-(methylsulfinyl)phenyl]methanamine hydrochloride (1.8 g) and triethylamine (2.4 ml) in methanol (5 ml) at room temperature, and the mixture was stirred overnight at 50° C. The reaction solvent was evaporated under reduced pressure, acetic acid (5 ml) was added, and the mixture was stirred at 50° C. for 2 hr. The solvent was evaporated under reduced pressure, the residue was partitioned with ethyl acetate, 1N aqueous sodium hydroxide solution and aqueous sodium bicarbonate, and the organic layer was dried over sodium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by basic silica gel column chromatography (ethyl acetate:hexane=7:3→1:0). 4N Hydrochloride-ethyl acetate solution (1 ml) was added to the obtained yellow oil, and the precipitated crystals were collected by filtration, and recrystallized to give the title compound (270 mg).

1. customThe reaction solvent was evaporated under reduced pressure, acetic acid (5 ml)
2. additionwas added
3. stirringthe mixture was stirred at 50° C. for 2 hr
4. customThe solvent was evaporated under reduced pressure
5. customthe residue was partitioned with ethyl acetate, 1N aqueous sodium hydroxide solution and aqueous sodium bicarbonate
6. dry with materialthe organic layer was dried over sodium sulfate
7. customThe solvent was evaporated under reduced pressure
8. customThe residue was purified by basic silica gel column chromatography (ethyl acetate:hexane=7:3→1:0)
9. addition4N Hydrochloride-ethyl acetate solution (1 ml) was added to the obtained yellow oil
10. filtrationthe precipitated crystals were collected by filtration
11. customrecrystallized