HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → methyl 2-[(3-carbamoyl-5-chloro-2-iminopyridin-1(2H)-yl)methyl]-4-chlorobenzoate hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Methyl 2-(bromomethyl)-4-chlorobenzoate | HCID 20814722 | — |
| Reactant | 2-Amino-5-chloronicotinamide | HCID 66876883 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | methyl 2-[(3-carbamoyl-5-chloro-2-iminopyridin-1(2H)-yl)methyl]-4-chlorobenzoate hydrobromide | HCID 66969549 | 15.2% |
Reaction Steps
(Step 3) A solution of 2-amino-5-chloronicotinamide (202 mg) and methyl 4-chloro-2-bromomethylbenzoate obtained in Step 2 (470 mg) in DMF (5 ml) was stirred overnight at 90° C. The mixture was allowed to cool to room temperature, ethyl acetate was added, and the precipitated crystals were collected by filtration. The obtained crystals were recrystallized from ethanol and ethyl acetate to give the title compound (78 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481569B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-b85af4f09b204dc8866cda9470800f6f |
| Source note | uspto-grants-2013_07 |