Hydrochloride methanol → HCID 66878439, compound

HRID 447868Notes

Reaction equation

HRID 447868 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:17]2[CH2:21][CH2:20][O:19][C:18]2=[O:22])=[C:6]([CH:16]=1)[CH2:7][NH:8]C(=O)OC(C)(C)C.Cl.CO>CO>[ClH:1].[NH2:8][CH2:7][C:6]1[CH:16]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=1[N:17]1[CH2:21][CH2:20][O:19][C:18]1=[O:22]

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 86650832HCID 86650832, compound

Product 1

HCID 66878439HCID 66878439, compoundYield 146.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(Step 3) To a solution of tert-butyl [5-chloro-2-(2-oxo-1,3-oxazolidin-3-yl)benzyl]carbamate obtained in Step 2 (2.21 g) in methanol (27 ml) was added 2N hydrogen chloride-methanol solution (10 ml) at room temperature, and the mixture was stirred for 3 hr. The reaction solution was concentrated under reduced pressure. The resulting crystals were collected by filtration, and washed with ethyl acetate to give 3-[2-(aminomethyl)-4-chlorophenyl]-1,3-oxazolidin-2-one hydrochloride (1.30 g) as a white solid.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. filtrationThe resulting crystals were collected by filtration
  3. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-56e3dd6a5ac244069045949a1864a36a
Source dataset
uspto-grants-2013_07
Patent number
US08481569B2

Reaction notes

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