Water → Thiourea, (4-phenyl-2-thiazolyl)-

HRID 447917Notes

Reaction equation

HRID 447917 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([NH:12][C:13]([NH:15]C(=O)C3C=CC=CC=3)=[S:14])[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O>CO.[OH-].[Na+]>[C:1]1([C:7]2[N:8]=[C:9]([NH:12][C:13]([NH2:15])=[S:14])[S:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 962WaterHCID 782761n-[(4-Phenyl-1,3-thiazol-2-yl)carbamothioyl]benzamide

Product 1

HCID 799782Thiourea, (4-phenyl-2-thiazolyl)-Yield 3.6%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

4.20 g N-{[(4-phenyl-1,3-thiazole-2-yl)amino]carbonothioyl}benzamide (339 mmol) were suspended in 40 ml methanol, were dissolved in aqueous sodium hydroxide (550 mg NaOH dissolved in 3 ml H2O) and were heated for 3 hours at reflux. The reaction mixture was evaporation-concentrated, the residue obtained was stirred with water and the precipitated solid was suction-isolated. After drying, 2.90 g of a light yellow solid were obtained.

Workup

  1. temperaturewere heated for 3 hours
  2. temperatureat reflux
  3. concentrationThe reaction mixture was evaporation-concentrated
  4. customthe residue obtained
  5. customthe precipitated solid was suction-isolated
  6. customAfter drying

Sources & evidence

ORD record
ord-ec189a0c6fb3470893817af03e8e17a8
Source dataset
uspto-grants-2013_07
Patent number
US08481576B2

Reaction notes

Loading…