HCID 7355185, compound → HCID 178489512, compound

Participants

Reaction Steps

Reaction of 100 mg (0.38 mmol) N-(2-chloro-1-piperidine-1-ylethylidene)-4-methylphenyl sulfonamide (preparation according to: Abdelaal, S.; Bauer, L. J. Het. Chem. 1988, 25 (6), 1849-1856) with 120 mg (0.38 mmol) N-[[(2-methoxybenzyl)amino](imino)-methyl]thiourea analogously to Example 3 yielded 12 mg of the desired product; ESI-MS [M+H+]=346.15. According to NMR, the compound exists as tautomeric mixture of 1-[2-({imino[(2-methoxybenzyl)amino]methyl}amino)-1,3-thiazole-4(5H)-ylidene]piperidine and N-(2-methoxybenzyl)-N′-(4-piperidine-1-yl-1,3-thiazole-2-yl)guanidine.

Provenance & Evidence