Potassium Hydroxide → 5-Methyl-1-(2-trimethylsilanyl-ethoxymethyl)-1h-imidazole-2-carboxylic acid potassium salt

HRID 448010Notes

Reaction equation

HRID 448010 reaction equation
C([O:3][C:4]([C:6]1[N:7]([CH2:12][O:13][CH2:14][CH2:15][Si:16]([CH3:19])([CH3:18])[CH3:17])[C:8]([CH3:11])=[CH:9][N:10]=1)=[O:5])C.[OH-].[K+:21]>C(O)C>[K+:21].[CH3:11][C:8]1[N:7]([CH2:12][O:13][CH2:14][CH2:15][Si:16]([CH3:17])([CH3:18])[CH3:19])[C:6]([C:4]([O-:5])=[O:3])=[N:10][CH:9]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 597712265-Methyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylic acid ethyl ester

Product 1

HCID 597712535-Methyl-1-(2-trimethylsilanyl-ethoxymethyl)-1h-imidazole-2-carboxylic acid potassium salt

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 5-methyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylic acid ethyl ester (as prepared in the previous step, 0.090 g, 0.32 mmol) in 2 mL of ethyl alcohol (EtOH) at RT was added 0.16 mL of 2N KOH. The mixture was stirred for 1 h and then concentrated and dried under vacuum to afford the title compound as a solid that was used without further purification.

Workup

  1. concentrationconcentrated
  2. customdried under vacuum

Sources & evidence

ORD record
ord-7f2d218973b045dea9491d547e42d2c9
Source dataset
uspto-grants-2013_07
Patent number
US08481564B2

Reaction notes

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