Hydrazine → (R)-8-cyclopentyl-7-ethyl-2-hydrazinyl-5-methyl-7,8-dihydropteridin-6(5H)-one

HRID 44803Notes

Reaction equation

HRID 44803 reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH3:12])[C:7](=[O:13])[C@@H:6]([CH2:14][CH3:15])[N:5]([CH:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)[C:4]=2[N:3]=1.[NH2:21][NH2:22]>C(O)C>[CH:16]1([N:5]2[C:4]3[N:3]=[C:2]([NH:21][NH2:22])[N:11]=[CH:10][C:9]=3[N:8]([CH3:12])[C:7](=[O:13])[C@H:6]2[CH2:14][CH3:15])[CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 24820413(R)-2-Chloro-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one

Product 1

HCID 58405330(R)-8-cyclopentyl-7-ethyl-2-hydrazinyl-5-methyl-7,8-dihydropteridin-6(5H)-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Intermediate B and hydrazine (6 equivalents) in ethanol was heated in a microwave for 1 h at 120° C. The solvent was removed to give Intermediate B-2. This material was used without further purification.

Workup

  1. customThe solvent was removed
  2. customto give Intermediate B-2
  3. customThis material was used without further purification

Sources & evidence

ORD record
ord-c585cc71d7264df784cfa8261c1f44c5
Source dataset
uspto-grants-2013_09
Patent number
US08541418B2

Reaction notes

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