HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenyl isocyanate → Methyl 1-N-(phenyl)carbamoyl-5-chlorooxindole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenyl isocyanate | HCID 7672 | — |
| Reactant | methyl 5-chloro-2-oxo-2,3-dihydro-1H-indole-3-carboxylate | HCID 21282067 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Methyl 1-N-(phenyl)carbamoyl-5-chlorooxindole-3-carboxylate | HCID 14097011 | — |
Reaction Steps
To 6.0 g. (0.027 mole) of methyl 5-chlorooxindole-3-carboxylate in 200 ml. of toluene was added 5.25 ml. (0.048 mole) of phenylisocyanate and the resulting reaction mixture heated to reflux overnight. The reaction mixture was cooled and diluted with petroleum ether to give, after filtration and drying, 2.0 g. of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04725616 |
| Source dataset | uspto-grants-1988_02 |
| ORD ID | ord-bbeceddc0faf432ab9c414f3a0a0c3be |
| Source note | uspto-grants-1988_02 |