3-Thenoyl chloride → HCID 53358958, compound

HRID 448170Notes

Reaction equation

HRID 448170 reaction equation
S1C=CC(C(Cl)=O)=C1.S1C=CC(C([O:16][C:17]2[CH:26]=[C:25]3[C:20]([C:21](=[O:43])[C:22]([C:32]4[CH:37]=[CH:36][C:35]([C:38]([O:40]CC)=[O:39])=[CH:34][CH:33]=4)=[C:23]([C:27]4[CH:31]=[CH:30][S:29][CH:28]=4)[O:24]3)=[CH:19][CH:18]=2)=O)=C1>>[OH:16][C:17]1[CH:26]=[C:25]2[C:20]([C:21](=[O:43])[C:22]([C:32]3[CH:37]=[CH:36][C:35]([C:38]([OH:40])=[O:39])=[CH:34][CH:33]=3)=[C:23]([C:27]3[CH:31]=[CH:30][S:29][CH:28]=3)[O:24]2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 27763773-Thenoyl chlorideHCID 67366892HCID 67366892, compound

Product 1

HCID 53358958HCID 53358958, compound

Procedure

Synthesis: Prepared following General Scheme 1, starting from Intermediate A-1a and thiophene-3-carbonyl chloride in step 1 using condition b) to 3-(4-(ethoxycarbonyl)phenyl)-4-oxo-2-(thiophen-3-yl)-4H-chromen-7-yl thiophene-3-carboxylate. Step 2 followed d) conditions. See Example 3 for detailed example.

Workup

  1. customSynthesis
  2. customPrepared

Sources & evidence

ORD record
ord-4904e8cb85724854b9f007dd9990ad50
Source dataset
uspto-grants-2013_07
Patent number
US08481590B2

Reaction notes

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