Carbon Disulfide → HCID 53357108, compound

Participants

Reaction Conditions

Reaction Steps

Synthesis: Step 1: Synthesis of methyl 4-(7-methoxy-2-(methylthio)-4-oxo-4H-chromen-3-yl)benzoate. A stirred mixture of Intermediate B (100 mg, 0.33 mmol) and carbon disulfide (127 mg, 1.67 mmol) in DMF (5.0 mL) was cooled to 0° C. and NaH (24 mg, 1.0 mmol) was added. The reaction mixture was stirred at 0 ° C. for 30 min. Then Mel (94 mg, 0.67 mmol) was added and the reaction mixture was stirred at room temperature for 3 h. The solution was diluted with water (10 mL), extracted with DCM (50 mL×3). The organic layers were dried over Na2SO4, concentrated and purified by silica gel column chromatography (PE:EA=3:1) to afford product (36 mg (not pure), 30%). MS (ESI): m/z 357.0 [M+1]+.

Provenance & Evidence