反应详情

温度

70 °C

A 3-L evaporation flask with magnetic stirrer, Claissen adapter, pot thermometer and a reflux condenser routed to a gas scrubber was charged with (+) 4-chlorophenyl-(3-trifluoromethylphenoxy)-acetic acid (131 g, 0.37 mole) and CHCl3 (152 ml) and heated to boiling in order to dissolve. SOCl2 (35 ml, 56.5 g, 0.48 mole) was added. The mixture was heated to reflux (70° C. final) for 4 hours and then stripped of volatiles to obtain 139 g liquid. The material was used in the next step without further purification.

1. customA 3-L evaporation flask with magnetic stirrer
2. customClaissen adapter, pot thermometer and a reflux condenser routed to a gas scrubber
3. temperatureheated
4. dissolutionto dissolve
5. temperatureThe mixture was heated