HCID 58307334, compound → HCID 58307289, compound

Participants

Reaction Steps

A mixture dimethyl-[2-(4-nitro-3-phenoxy-phenoxy)-ethyl]-amine (3.0 g, 9.9 mmol) and 5% Pd—C (0.6 g) in ethyl acetate (100 mL) was shaken under 50 psi of hydrogen for 20 hours. The mixture was filtered through Celite and evaporated, providing 2.7 g of the product, in quantitative yield; 1H NMR (CDCl3) δ 2.30 (s, 6H), 2.65 (t, J=5.7 Hz, 2H), 3.93 (t, J=5.7 Hz, 2H), 6.51 (d, J=2.6 Hz, 1H), 6.60 (dd, J=8.6 Hz, J=2.9 Hz, 1H), 6.74 (d, J=8.6 Hz, 1H), 6.95-7.00 (m, 2H), 7.06 (t, J=7.3 Hz, 1H), 7.28-7.34 (m, 2H).

Provenance & Evidence