Potassium Hydroxide → 1-[2-(3-Methoxy-4-nitro-phenoxy)-ethyl]-piperidine

Participants

Reaction Conditions

Reaction Steps

1-Piperidineethanol (1.8 g, 14 mmol) was added to a mixture of powdered KOH (0.78 g, 14 mmol) and Aliquat 336 (0.56 g, 1.4 mmol), and the resulting mixture was stirred for 5 minutes at 80° C. Then 4-fluoro-2-methoxy-1-nitrobenzene (2.0 g, 12 mmol) was added, and stirring proceeded at this temperature for 30 minutes. The mixture was cooled and partitioned between methylene chloride (75 mL) and water (75 mL), and the organic phase was washed with water (75 mL) and extracted with dilute aqueous HCl (3×60 mL). The combined aqueous phases were washed with methylene chloride (3×75 mL), basified (3N NaOH), and extracted with methylene chloride (3×75 mL). The combined organic extracts were washed with water (3×100 mL), dried (MgSO4), and evaporated, providing 1.6 g, in 49% yield; 1H NMR (DMSO-d6) δ 1.48-1.53 (m, 6H), 2.40-2.44 (m, 4H), 2.67 (t, J=5.8 Hz, 2H), 3.93 (s, 3H), 4.21 (t, J=5.8 Hz, 2H), 6.67 (dd, J=9.3 Hz, J=1.5 Hz, 1H), 6.81 (d, J=1.5 Hz, 1H), 7.95 (d, J=9.3 Hz, 1H).

Provenance & Evidence