Hydrochloric Acid → Alpha-Lipoic Acid Alpha Cyclodextrin

Participants

Reaction Steps

1.44 moles of potassium hydroxide were added to 5.5 kg of water and mixed at room temperature until clear. The pH of this solution was at pH 14. 300 g alpha-lipoic acid (98%, 1.425 moles) was added to the potassium hydroxide solution and mixed until clear (in case of the presence of amorphous silica as flowing agent the solution will be slightly cloudy). 1.553 kg of dry alpha cyclodextrin (1.598 moles) was added and stirred 50 minutes at room temperature. 1.44 moles of 37% hydrochloric acid was added precipitating the complex. This mixture was stirred 30 minutes at room temperature. The final pH was at about pH 3. This aqueous mixture was spray dried immediately at about 180° C. inlet and about 80° C. outlet temperature.

Provenance & Evidence