Trifluoroacetic acid → (R)-N-(4-(7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)pyridin-3-yl)-3,3-dimethylbutanamide

Participants

Reaction Steps

The title compound was prepared similarly to the methods described in Example 102, with (R)-2-(3-aminopyridin-4-yl)-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 93) instead of (R)-2-(3-aminopyridin-4-yl)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 91) and with 3,3-dimethylbutanoic acid instead of benzoic acid. LCMS (0.05% TFA): 425.3 m/z (M+H)+; 1H-NMR (DMSO-d6, 500 MHz): δ: 12.93 (bs, 1H), 9.89 (bs, 1H), 8.50 (bs, 2H), 8.30 (s, 1H), 4.59 (m, 1H), 4.49 (m, 1H), 3.36 (s, 3H), 2.37 (s, 2H), 1.87 (m, 1H), 1.77 (m, 1H), 1.45 (m, 6H), 0.77 (t, 3H, J=7.5 Hz).

Provenance & Evidence