HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[6-(5-Methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid 1-benzyl-pyrrolidin-3-yl ester → 4-[6-(5-Methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid pyrrolidin-3-yl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[6-(5-Methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid 1-benzyl-pyrrolidin-3-yl ester | HCID 66900688 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-[6-(5-Methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid pyrrolidin-3-yl ester | HCID 49848659 | — |
Reaction Steps
23a (0.2 mmol) and 30 mg of Pd/C in 3 mL of ethanol were stirred under 60 psi of hydrogen for 12 h. The suspension was filtered on celite with ethanol, evaporated and purified by preparative HPLC to afford 23-1, LCMS 488.1 (MH+). tR=5.21 (Method 5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481731B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-bfd4dd1862b34fd6be81010b797df355 |
| Source note | uspto-grants-2013_07 |