Trifluoroacetic acid → HCID 58405743, compound

Participants

Reaction Steps

The title compound was prepared similarly to the methods described in Example 102, with (R)-2-(3-(aminomethyl)pyridin-4-yl)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 105) instead of (R)-2-(3-aminopyridin-4-yl)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 91). LCMS (0.05% TFA): 471.3 m/z (M+H)+; 1H-NMR (CDCl3, 500 MHz): δ: 9.03 (bs, 1H), 8.83 (bs, 1H), 8.38 (bs, 1H), 8.03 (bs, 1H), 7.78 (d, 2H, J=9 Hz), 7.50 (t, 1H, J=9.0 Hz), 7.42 (t, 2H, J=9.0 Hz), 5.02 (s, 2H), 4.49 (m, 1H), 4.39 (m, 1H), 3.42 (s, 3H), 2.16-1.68 (m, 10H), 0.91 (t, 3H, J=7.5 Hz).

Provenance & Evidence