Trifluoroacetic acid → HCID 58405479, compound

Participants

Reaction Steps

The title compound was prepared similarly to the methods described in Example 102, with (R)-2-(3-(aminomethyl)pyridin-4-yl)-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 126) instead of (R)-2-(3-aminopyridin-4-yl)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 91), and with acetic acid instead of benzoic acid. LCMS (0.05% TFA): 383.2 m/z (M+H)+; 1H-NMR (MeOD, 500 MHz): δ: 8.51 (s, 1H), 8.46 (d, 1H, J=5.0 Hz), 8.04 (s, 1H), 7.84 (d, 1H, J=5.0 Hz), 4.70 (d, 2H, 10.5 Hz), 4.61 (m, 1H), 4.33 (m, 1H), 3.31 (s, 3H), 1.85 (s, 3H), 1.83 (m, 1H), 1.69 (m, 1H), 1.35 (d, 3H, J=6.5 Hz), 1.32 (d, 3H, J=6.5 Hz), 0.77 (t, 3H, J=7.5 Hz).

Provenance & Evidence