Trifluoroacetic acid → HCID 58405832, compound

Participants

Reaction Steps

The title compound was prepared similarly to the methods described in Example 102, with (R)-2-(3-(aminomethyl)pyridin-4-yl)-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 126) instead of (R)-2-(3-aminopyridin-4-yl)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 91). LCMS (0.05% TFA): 445.2 m/z (M+H)+; 1H-NMR (MeOD, 500 MHz): δ: 8.89 (bs, 1H), 8.82 (bs, 1H), 8.43 (d, 1H, J=5.0 Hz), 8.24 (s, 1H), 7.80 (d, 2H, J=7.5 Hz), 7.57 (t, 1H, J=7.5 Hz), 7.47 (t, 2H, J=7.5 Hz), 5.12 (d, 2H, J=6 Hz), 4.73 (m, 1H), 4.49 (m, 1H), 3.42 (s, 3H), 1.99 (m, 1H), 1.81 (m, 1H), 1.46 (t, 6H, J=7.5 Hz), 0.87 (t, 3H, J=7.5 Hz).

Provenance & Evidence