Trifluoroacetic acid → (R)-N-((4-(7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)pyridin-3-yl)methyl)methanesulfonamide

Participants

Reaction Steps

The title compound was prepared similarly to the methods described in Example 114, with (R)-2-(3-(aminomethyl)pyridin-4-yl)-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 126) instead of (R)-2-(3-aminopyridin-4-yl)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 91) and with methane sulfonylchloride instead of chloromethylcarbonate. LCMS (0.05% TFA): 419.2 m/z (M+H)+; 1H-NMR (DMSO-d6, 500 MHz): δ: 8.87 (s, 1H), 8.81 (d, 1H, J=5.0 Hz), 8.27 (d, 1H, J=5.0 Hz), 8.22 (s, 1H), 4.75 (d, 2H, J=5.0 Hz), 4.60 (m, 1H), 4.44 (m, 1H), 3.33 (s, 3H), 2.93 (s, 3H), 1.84 (m, 1H), 1.73 (m, 1H), 1.36 (t, 6H, J=7.5 Hz), 0.76 (t, 3H, J=7.5 Hz).

Provenance & Evidence