HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 44869Generated: October 28, 2026
(R)-8-cyclopentyl-7-ethyl-5-methyl-2-(2-oxo-2-phenylethyl)-7,8-dihydropteridin-6(5H)-one → (R,Z)-8-cyclopentyl-2-(1-(dimethylamino)-3-oxo-3-phenylprop-1-en-2-yl)-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one
https://huagongshe.com/reaction/44869
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (R)-8-cyclopentyl-7-ethyl-5-methyl-2-(2-oxo-2-phenylethyl)-7,8-dihydropteridin-6(5H)-one | HCID 58405778 | — |
| Solvent | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Product | (R,Z)-8-cyclopentyl-2-(1-(dimethylamino)-3-oxo-3-phenylprop-1-en-2-yl)-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one | HCID 58405816 | — |
Reaction Steps
A suspension of (R)-8-cyclopentyl-7-ethyl-5-methyl-2-(2-oxo-2-phenylethyl)-7,8-dihydropteridin-6(5H)-one (Intermediate B-1, 700 mg) in 10 mL of DMF-DMA was heated at 110° C. for 3 hours. The resulting mixture was concentrated to give the desired (R,Z)-8-cyclopentyl-2-(1-(dimethylamino)-3-oxo-3-phenylprop-1-en-2-yl)-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one (compound I-132).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08541418B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-ccdd0958a18a4516abb7508bdf689562 |
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| Source note | uspto-grants-2013_09 |
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