反应详情

温度

-78 °C

The compound from Step B (80, mg) was dissolved in the minimum amount of 1,4-dioxane and placed in a stainless steel bomb. The bomb was cooled to −78° C. and liquid ammonia was added. The bomb was sealed and heated at 90° C. for 24 h. The ammonia was allowed to evaporate and the residue concentrated to a white solid which was used in the next step without further purification.

1. customThe bomb was sealed
2. temperatureheated at 90° C. for 24 h
3. customto evaporate
4. concentrationthe residue concentrated to a white solid which
5. customwas used in the next step without further purification