Triacetoxyperiodinane → HCID 67142734, compound

Participants

Reaction Conditions

Reaction Steps

The product (2.0 g, 4.0 mmol) from Step B and Dess-Martin periodinane (2.0 g) in dichloromethane (30 mL) were stirred overnight at room temperature and was then concentrated under reduced pressure. The residue was triturated with ether ether (50 mL) and filtered. The filtrate was washed with a solution of Na2S2O3.5H2O (2.5 g) in saturated aqueous sodium bicarbonate solution (50 mL), dried (MgSO4), filtered and evaporated. The residue was dissolved in anhydrous Et2O (20 mL) and was added dropwise to a solution of MeMgBr in Et2O (3 M, 10 mL) at −78° C. The reaction mixture was allowed to warm to −30° C. and stirred at −30° C. to −15° C. for 5 h, then poured into saturated aqueous ammonium chloride (50 mL). The two layers were separated and the organic layer was dried (MgSO4), filtered and concentrated. The residue was chromatographed on silica gel (EtOAc/hexane:1/9) to afford the title compound as a syrup (1.40 g).

Provenance & Evidence