(R)-2-chloro-8-cyclopropyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one → (R)-8-cyclopropyl-7-ethyl-5-methyl-2-(3-phenylpyridin-4-yl)-7,8-dihydropteridin-6(5H)-one

Participants

Reaction Steps

The title compound was prepared similarly to the methods described in Example 5, with Intermediate O instead of Intermediate B and with 3-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (Boronic Acid 2) instead of pyridin-4-ylboronic acid. LCMS: 386.2 m/z (M+H)+; ret. Time: 6.04 min (Analytical Method C).

Provenance & Evidence