反应详情

A solution of 491 mg (2 mmol) of 2-[(E)-2-(2-furanyl)ethenyl]-3-oxo-1-azaspiro[4.5]dec-1-en-4-one and 597 mg (4 mmol) of L-methionine in 20 ml of N-methylmorpholine was heated under reflux for 15 hours. After ethyl acetate and water were added to the reaction solution, it was acidified using concentrated hydrochloric acid. The organic layer was separated, it was successively washed with water and saturated brine, and dried with anhydrous sodium sulfate. After the solvent was distilled off under reduced pressure, it was purified by silica gel chromatography to obtain 74 mg (9%) of the title compound.

1. temperatureunder reflux for 15 hours
2. customThe organic layer was separated
3. washit was successively washed with water and saturated brine
4. dry with materialdried with anhydrous sodium sulfate
5. distillationAfter the solvent was distilled off under reduced pressure, it
6. customwas purified by silica gel chromatography