4-(1H-imidazol-2-yl)benzonitrile → (R)-4-(1-(7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)-1H-imidazol-2-yl)benzonitrile
Reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH3:12])[C:7](=[O:13])[C@@H:6]([CH2:14][CH3:15])[N:5]([CH:16]([CH3:18])[CH3:17])[C:4]=2[N:3]=1.[C:19]([C:21]1[CH:26]=[CH:25][C:24]([C:27]2[NH:28][CH:29]=[CH:30][N:31]=2)=[CH:23][CH:22]=1)#[N:20]>>[CH2:14]([C@H:6]1[N:5]([CH:16]([CH3:18])[CH3:17])[C:4]2[N:3]=[C:2]([N:28]3[CH:29]=[CH:30][N:31]=[C:27]3[C:24]3[CH:23]=[CH:22][C:21]([C:19]#[N:20])=[CH:26][CH:25]=3)[N:11]=[CH:10][C:9]=2[N:8]([CH3:12])[C:7]1=[O:13])[CH3:15]Participants
3
Procedure
The title compound was prepared similarly to the methods described in Example 26, with Intermediate C instead of Intermediate B and with 2-(4-cyanophenyl)-1H-imidazole instead of 2-phenyl-1H-imidazole. LCMS: 402.2 m/z (M+H)+; ret. Time: 6.26 min (Analytical Method C).
Sources & evidence
- ORD record
- ord-a3810d315d5e4d25b7b39ff9cee84aef
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08541418B2
Reaction notes
Loading…