HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(1H-Imidazol-2-yl)benzonitrile → (R)-3-(1-(7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)-1H-imidazol-2-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(1H-Imidazol-2-yl)benzonitrile | HCID 22335082 | — |
| Reactant | (R)-2-Chloro-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropyrimido[4,5-b]pyrazine | HCID 58405561 | — |
| Product | (R)-3-(1-(7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)-1H-imidazol-2-yl)benzonitrile | HCID 58405344 | — |
Reaction Steps
The title compound was prepared similarly to the methods described in Example 26, with Intermediate C instead of Intermediate B and with 2-(3-cyanophenyl)-1H-imidazole instead of 2-phenyl-1H-imidazole. LCMS: 402.2 m/z (M+H)+; ret. Time: 5.97 min (Analytical Method C).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08541418B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-5189f4ffbe664029bd64a5307cc33142 |
| Source note | uspto-grants-2013_09 |