2-(3,4-Difluoro-phenyl)-1H-imidazole → HCID 58405949, compound

HRID 44882Notes

Reaction equation

HRID 44882 reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH3:12])[C:7](=[O:13])[C@@H:6]([CH2:14][CH3:15])[N:5]([CH:16]3[CH2:19][CH:18]([F:20])[CH2:17]3)[C:4]=2[N:3]=1.[F:21][C:22]1[CH:23]=[C:24]([C:29]2[NH:30][CH:31]=[CH:32][N:33]=2)[CH:25]=[CH:26][C:27]=1[F:28]>>[F:21][C:22]1[CH:23]=[C:24]([C:29]2[N:33]([C:2]3[N:11]=[CH:10][C:9]4[N:8]([CH3:12])[C:7](=[O:13])[C@@H:6]([CH2:14][CH3:15])[N:5]([CH:16]5[CH2:19][CH:18]([F:20])[CH2:17]5)[C:4]=4[N:3]=3)[CH:32]=[CH:31][N:30]=2)[CH:25]=[CH:26][C:27]=1[F:28]

Participants

3

Reactant 2

HCID 584053162-(3,4-Difluoro-phenyl)-1H-imidazoleHCID 58405575HCID 58405575, compound

Product 1

HCID 58405949HCID 58405949, compound

Procedure

The title compound was prepared similarly to the methods described in Example 77, with Intermediate W instead of Intermediate C and with 2-(3,4-difluorophenyl)-1H-imidazole instead of 2-phenyl-1H-imidazole. LCMS: 443.1 m/z (M+H)+; ret. Time: 6.85 min (Analytical Method C).

Sources & evidence

ORD record
ord-e084b8d272ba40f390c3f25d8b109769
Source dataset
uspto-grants-2013_09
Patent number
US08541418B2

Reaction notes

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