N2,N2,3-trimethylpyridine-2,5-diamine → N-[6-(Dimethylamino)-5-methylpyridin-3-yl]-5-fluoro-1-(pyridin-4-ylmethyl)-1H-indole-2-carboxamide
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1)[C:6]([C:18]([OH:20])=O)=[CH:5]2.[NH2:21][C:22]1[CH:23]=[N:24][C:25]([N:29]([CH3:31])[CH3:30])=[C:26]([CH3:28])[CH:27]=1>>[CH3:30][N:29]([CH3:31])[C:25]1[N:24]=[CH:23][C:22]([NH:21][C:18]([C:6]2[N:7]([CH2:11][C:12]3[CH:13]=[CH:14][N:15]=[CH:16][CH:17]=3)[C:8]3[C:4]([CH:5]=2)=[CH:3][C:2]([F:1])=[CH:10][CH:9]=3)=[O:20])=[CH:27][C:26]=1[CH3:28]Participants
3
Procedure
Compound No. 19 is prepared from 5-fluoro-1-(pyridin-4-ylmethyl)-1H-indole-2-carboxylic acid, synthesized in stage 5.1, and 3-amino-5-methyl-6-(dimethylamino)pyridine (GB 870 027) according to a process similar to that described in example No. 3.
Sources & evidence
- ORD record
- ord-576787909acf49c883ae5247b29cb407
- Source dataset
- uspto-grants-2013_07
- Patent number
- US08481745B2
Reaction notes
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