Ethylenediamine → HCID 58405862, compound

HRID 44884Notes

Reaction equation

HRID 44884 reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH3:12])[C:7](=[O:13])[C@@H:6]([CH2:14][CH3:15])[N:5]([CH:16]([CH3:18])[CH3:17])[C:4]=2[N:3]=1.[CH2:19]([NH2:22])[CH2:20][NH2:21]>>[NH2:21][CH2:20][CH2:19][NH:22][C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH3:12])[C:7](=[O:13])[C@@H:6]([CH2:14][CH3:15])[N:5]([CH:16]([CH3:18])[CH3:17])[C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 3301EthylenediamineHCID 58405561(R)-2-Chloro-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropyrimido[4,5-b]pyrazine

Product 1

HCID 58405862HCID 58405862, compound

Procedure

Intermediate C (1 mmol, 269 mg) in ethylenediamine (10 mmol, 600 mg, 0.7 mL) was heated at 120° C. in a microwave for 3 h. The reaction was evaporated, taken up in EtOAc and washed 3× with water, then dried with MgSO4 and evaporated to give (R)-2-(2-aminoethylamino)-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one (compound I-246).

Workup

  1. customThe reaction was evaporated
  2. washwashed 3× with water
  3. dry with materialdried with MgSO4
  4. customevaporated

Sources & evidence

ORD record
ord-1911f42a7db34c9fb532cfdbb8ea8761
Source dataset
uspto-grants-2013_09
Patent number
US08541418B2

Reaction notes

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