化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → 3-Bromo-4-chlorobenzoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 3-Bromo-4-chlorobenzoic acid | HCID 2735544 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-Bromo-4-chlorobenzoyl chloride | HCID 20229730 | — |
反応手順
To 3-bromo-4-chloro-benzoic acid (9.4 g, 40 mmol) in dry DCM (100 mL), was added DMF (0.5 mL) followed by addition of oxalyl chloride (22.5 mL, 55 mmol, 2M in DCM) slowly. The mixture was stirred for 1 hr, then concentrated to yield 3-bromo-4-chloro-benzoyl chloride as an off-white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08481738B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-ba4a4e095ecf4ceb89ab34898d1ebac1 |
| 出典メモ | uspto-grants-2013_07 |