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Acetyl chloride → Methyl 3-bromo-4-chlorobenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | 3-Bromo-4-chlorobenzoic acid | HCID 2735544 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl 3-bromo-4-chlorobenzoate | HCID 22352523 | 99.7% |
反応手順
To a suspension of 3-bromo-4-chloro-benzoic acid (10 g, 42.6 mmol) in MeOH (100 mL) cooled with ice bath, was added acetyl chloride (30.4 mL, 0.43 mol) dropwise. The mixture was then stirred at room temperature for 12 hrs and concentrated to yield 3-bromo-4-chloro-benzoic acid methyl ester as a yellow solid (10.6 g). NMR (CDCl3), δ, 8.28 (1H, s), 7.91 (1H, brs), 7.52 (1H, brs), 3.92 (3H, s).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08481738B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-11bf426226394b768f4592d86dd9632a |
| 出典メモ | uspto-grants-2013_07 |