反应详情

To (2-amino-6-fluoro-phenyl)-methanol (2.49 g, 17.3 mmol) in dichloromethane (30 mL) was added MnO2 (3.01 g, 34.7 mmol, activated). The mixture was refluxed for 3 hrs and then filtered over celite. The mixture was concentrated and purified via silica gel flash chromatography (eluting with 30% ethyl acetate in hexane) to give 2-amino-6-fluoro-benzaldehyde as a yellow solid (1.23 g). tR=2.20 min. (method 1)

1. temperatureThe mixture was refluxed for 3 hrs
2. filtrationfiltered over celite
3. concentrationThe mixture was concentrated
4. custompurified via silica gel flash chromatography (eluting with 30% ethyl acetate in hexane)