3-bromo-4-chloro-N-(2-hydroxy-phenyl)-N-methyl-benzamide → 4-{2-[(3-Bromo-4-chloro-benzoyl)-methyl-amino]-phenoxy}-butyric acid tert-butyl ester

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Reaction Steps

4-{2-[(3-Bromo-4-chloro-benzoyl)methyl-amino]-phenoxy}-butyric acid tert-butyl ester (6.24 g) was similarly prepared according to Step 3C as a light yellow solid from 3-bromo-4-chloro-N-(2-hydroxy-phenyl)-N-methyl-benzamide (7.9 g, 23.2 mmol). MS [M-tert-but]+: 426.0/428.0; tR=2.69 min. (method 1)

Provenance & Evidence