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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 448939Generated: October 29, 2026

3-Borono-4-chlorobenzoic acid → 4-Chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-benzoic acid

https://huagongshe.com/reaction/448939

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Borono-4-chlorobenzoic acidHCID 17750228—
Reactant5-Bromo-2-(trifluoromethyl)isonicotinonitrileHCID 56973315—
Product4-Chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-benzoic acidHCID 68602445—

Reaction Steps

Similarly, 4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-benzoic acid was prepared according to the above procedure from 5-carboxy-2-chloro-phenylboronic acid and 5-bromo-2-trifluoromethyl-isonicotinonitrile 1-1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08481738B2
Source datasetuspto-grants-2013_07
ORD IDord-6a4b1e216e694b15af581e2f575cc73a
Source noteuspto-grants-2013_07