3-Cyclobutyl-1-iodoimidazo[1,5-a]pyrazin-8-amine → HCID 178501065, compound

HRID 448962Notes

Reaction equation

HRID 448962 reaction equation
C1(C2N3C=CN=C(N)C3=C(I)[N:6]=2)CCC1.[CH3:16][O:17][C:18]([C@H:20]1[CH2:25][CH2:24][C@H:23]([C:26]2[N:30]3[CH:31]=[CH:32][N:33]=[C:34](Cl)[C:29]3=[C:28]([I:36])[N:27]=2)[CH2:22][CH2:21]1)=[O:19]>>[CH3:16][O:17][C:18]([C@H:20]1[CH2:25][CH2:24][C@H:23]([C:26]2[N:30]3[CH:31]=[CH:32][N:33]=[C:34]([NH2:6])[C:29]3=[C:28]([I:36])[N:27]=2)[CH2:22][CH2:21]1)=[O:19]

Participants

3

Reactant 2

HCID 426093653-Cyclobutyl-1-iodoimidazo[1,5-a]pyrazin-8-amineHCID 178501064HCID 178501064, compound

Product 1

HCID 178501065HCID 178501065, compound

Procedure

Prepared according to the procedure described above for 3-cyclobutyl-1-iodoimidazo[1,5-a]pyrazin-8-amine, except using trans-4-(8-Chloro-1-iodo-imidazo[1,5-a]pyrazin-3-yl)-cyclohexanecarboxylic acid methyl ester. 1H NMR (d6-DMSO): δ 7.65 (d, J=4.8 Hz, 1H), 6.96 (d, J=4.8 Hz, 1H), 6.52 (br s, 2H), 3.65 (s, 3H), 3.16 (m, 1H), 2.71 (m, 1H), 2.15-2.00 (m, 2H), 1.80-1.60 (m, 6H) MS (ES+): m/z 400.98 (100) [M+1].

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e0f8c4b3921e42a1b71be72eba9df570
Source dataset
uspto-grants-2013_07
Patent number
US08481733B2

Reaction notes

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