3-Cyclobutyl-1-iodoimidazo[1,5-a]pyrazin-8-amine → HCID 66915553, compound

HRID 448973Notes

Reaction equation

HRID 448973 reaction equation
C1(C2N3C=CN=C(N)C3=C(I)[N:6]=2)CCC1.Cl[C:17]1[C:18]2[N:19]([C:23]([CH:27]3[CH2:30][C:29]([F:32])([F:31])[CH2:28]3)=[N:24][C:25]=2[I:26])[CH:20]=[CH:21][N:22]=1>>[F:31][C:29]1([F:32])[CH2:30][CH:27]([C:23]2[N:19]3[CH:20]=[CH:21][N:22]=[C:17]([NH2:6])[C:18]3=[C:25]([I:26])[N:24]=2)[CH2:28]1

Participants

3

Reactant 2

HCID 426093653-Cyclobutyl-1-iodoimidazo[1,5-a]pyrazin-8-amineHCID 86636022HCID 86636022, compound

Product 1

HCID 66915553HCID 66915553, compound

Procedure

Prepared according to the procedure described above for 3-cyclobutyl-1-iodoimidazo[1,5-a]pyrazin-8-amine, except using 8-chloro-3-(3,3-difluoro-cyclobutyl)-1-iodo-imidazo[1,5-a]pyrazine. HPLC: tR=1.87 min. (Open Lynx polar—5 min). MS (ES+): m/z 350.74 (100) [MH+].

Workup

  1. customPrepared
  2. customHPLC: tR=1.87 min. (Open Lynx polar—5 min)

Sources & evidence

ORD record
ord-9980552c3b6f42a6acf1c03c736ec990
Source dataset
uspto-grants-2013_07
Patent number
US08481733B2

Reaction notes

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