3-Cyclobutyl-1-iodoimidazo[1,5-a]pyrazin-8-amine → HCID 69016061, compound

HRID 448974Notes

Reaction equation

HRID 448974 reaction equation
[CH:1]1([C:5]2[N:9]3[CH:10]=[CH:11][N:12]=[C:13]([NH2:14])[C:8]3=[C:7]([I:15])[N:6]=2)[CH2:4][CH2:3][CH2:2]1.ClC1[C:18]2[N:19](C(C3CC(N(C)C)C3)=NC=2I)[CH:20]=CN=1>>[CH3:18][N:19]([CH3:20])[CH:3]1[CH2:2][CH:1]([C:5]2[N:9]3[CH:10]=[CH:11][N:12]=[C:13]([NH2:14])[C:8]3=[C:7]([I:15])[N:6]=2)[CH2:4]1

Participants

3

Reactant 2

HCID 426093653-Cyclobutyl-1-iodoimidazo[1,5-a]pyrazin-8-amineHCID 86636023HCID 86636023, compound

Product 1

HCID 69016061HCID 69016061, compound

Procedure

Prepared according to the procedure described above for 3-cyclobutyl-1-iodoimidazo[1,5-a]pyrazin-8-amine, except using [3-(8-Chloro-1-iodo-imidazo[1,5-a]pyrazin-3-yl)-cyclobutyl]-dimethyl-amine. 1H NMR (400 MHz, CDCl3): δ 2.25 (br.s, 6H), 2.47 (br.s, 2H), 2.63 (q, J=8.17 Hz, 2H), 2.93 (br.s, 1H), 3.30-3.41 (m, 1H), 5.64 (br.s, 2H), 7.03 (d, J=4.80 Hz, 1H), 7.22 (d, J=4.80 Hz, 1H). HPLC: tR=0.36 min. (Open Lynx polar—5 min.). MS (ES+): m/z 357.73 (100) [MH+].

Workup

  1. customPrepared
  2. customHPLC: tR=0.36 min. (Open Lynx polar—5 min.)

Sources & evidence

ORD record
ord-bea0465ff8834c538bbbaba2d32a4872
Source dataset
uspto-grants-2013_07
Patent number
US08481733B2

Reaction notes

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