Dimethylamine, hydrochloride → HCID 86636023, compound

Participants

Reaction Steps

To a dry flask loaded with 3-(8-chloro-1-iodo-imidazo[1,5-a]pyrazin-3-yl)-cyclobutanone (400.0 mg, 1.15 mmol) in THF (9.0 mL) was added DIEA (0.42 ml, 2.42 mmol), dimethylamine hydrochloride (0.19 g, 2.30 mmol) followed by sodium triacetoxyborohydride (539 mg, 2.42 mmol) at rt. The resulting mixture was stirred at room temperature overnight. The reaction mixture was extracted with aq. Solution of NaHCO3 (2×30 mL). The aq.—layer was back-extracted with EtOAc (2×100 mL), dried (Na2SO4) and concentrated in vacuo to a solid. The material was carried onto the next step without any further purification. MS (ES+): m/z 344.73/345.81 (100/10) [MH+]

Provenance & Evidence