Benzyl 4-(8-amino-1-iodoimidazo[1,5-a]pyrazin-3-yl)piperidine-1-carboxylate → 1-Iodo-3-piperidin-4-yl-imidazo[1,5-a]pyrazin-8-ylamine

Participants

Reaction Steps

Benzyl 4-(8-amino-1-iodoimidazo[1,5-a]pyrazin-3-yl)piperidine-1-carboxylate (1.00 g. 2.10 mmol) was dissolved in concentrated HCl (30 mL) at 0° C. The reaction was stirred at rt. overnight. The reaction mixture was diluted with water (30 mL) and washed with EtOAc (30 mL×3), the aqueous phase was removed under reduced pressure to give a residue which was used for next step without further purification. MS (ES+): m/z 343.78 [MH+].

Provenance & Evidence