Cyclohexanecarboxylic acid → HCID 44539001, compound

Participants

Reaction Steps

Prepared according to a procedure analogous to that described for synthesis of [4-(8-amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)-3,6-dihydro-2H-pyridin-1-yl]-phenylmethanone, except using cyclohexanecarboxylic acid. 1H NMR (400 MHz, CDCl3): δ=1.25-1.40 (m, 3H) 1.60 (br. s., 2H) 1.85 (dd, J=8.97, 2.65 Hz, 5H) 2.05 (dd, J=8.84, 3.28 Hz, 1H) 2.14-2.27 (m, 1H) 2.42-2.64 (m, 5H) 2.78 (br. s., 2H) 3.69-3.97 (m, 3H) 4.31 (br. s., 2H) 6.07 (br. s., 1H) 6.83 (br.s., 1H) 7.01 (d, J=5.05 Hz, 1H). MS (ES+): m/z 380.03 (100) [MH+]. HPLC: tR=2.27 min (ZQ3, polar—5 min).

Provenance & Evidence