2-Fluorobenzoic acid → HCID 57960981, compound

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Reaction Steps

Prepared according to a procedure analogous to that described for synthesis of [4-(8-amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)-3,6-dihydro-2H-pyridin-1-yl]-phenylmethanone except using 2-fluorobenzoic acid. 1H NMR (400 MHz, CDCl3): δ=2.03 (ddd, J=11.75, 8.84, 3.16 Hz, 1H) 2.16 (ddd, J=14.46, 9.03, 5.56 Hz, 1H) 2.41-2.63 (m, 4H) 2.78 (br. s., 1H) 2.88 (br. s., 1H) 3.64 (t, J=5.05 Hz, 1H) 3.76 (quin, J=8.59 Hz, 1H) 4.11 (t, J=5.81 Hz, 2H) 4.51 (d, J=2.53 Hz, 1H) 5.82-6.12 (m, 1H) 6.64 (br. s., 2H) 6.87-6.98 (m, 1H) 7.04 (dd, J=5.31, 1.77 Hz, 1H) 7.15 (td, J=8.91, 3.66 Hz, 1H) 7.20-7.25 (m, 0H) 7.41-7.50 (m, 2H). MS (ES+): m/z 391.96 (100) [MH+]. HPLC: tR=2.16 min (OpenLynx polar—5 min).

Provenance & Evidence