HCID 178427763, compound → HCID 178461454, compound

HRID 449068Notes

Reaction equation

HRID 449068 reaction equation
[CH3:1][C@@H:2]1[CH2:5][C@H:4]([C:6]2[N:10]3[CH:11]=[CH:12][N:13]=[C:14]([NH2:15])[C:9]3=[C:8]([C:16]3[CH:21]=[CH:20][C:19]([O:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)=[CH:18][CH:17]=3)[N:7]=2)[CH2:3]1.NC1C2N(C([C@H]3C[C@H](COS(C4C=CC(C)=CC=4)(=O)=O)C3)=NC=2C2C=CC(OC3C=CC=CC=3)=CC=2)C=CN=1>>[CH3:1][C@H:2]1[CH2:5][C@H:4]([C:6]2[N:10]3[CH:11]=[CH:12][N:13]=[C:14]([NH2:15])[C:9]3=[C:8]([C:16]3[CH:21]=[CH:20][C:19]([O:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)=[CH:18][CH:17]=3)[N:7]=2)[CH2:3]1

Participants

3

Reactant 2

HCID 178427763HCID 178427763, compoundHCID 178461453HCID 178461453, compound

Product 1

HCID 178461454HCID 178461454, compound

Procedure

Prepared according to the procedure described above for cis-3-(3-methylcyclobutyl)-1-(4-phenoxyphenyl)-imidazo[1,5-a]pyrazin-8-ylamine, except using trans-toluene-4-sulfonic acid 3-[8-amino-1-(4-phenoxyphenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclobutylmethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-90cd18072a3b4d16876fd76dab9c08b8
Source dataset
uspto-grants-2013_07
Patent number
US08481733B2

Reaction notes

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