Dimethylformamide → HCID 57960989, compound

Participants

Reaction Conditions

Reaction Steps

Into a 10 mL round bottom flask was added 4-(8-amino-3-cyclobutylimidazo[1,5-a]pyrazin-2-yl)phenol (20 mg, 0.00007 mol), benzonitrile, 2-fluoro-(0.017 g, 0.00014 mol), potassium carbonate (0.015 g, 0.00011 mol), DMF (0.6 mL, 0.007 mol) and the reaction was heated at 120° C. for 4 h. Purification by Gilson HPLC afforded 5.0 mg of the title compound as a white solid. The compound was passed through an SPE cartridge washing with NH3 in MeOH to elute 4.8 my of the desired compound free of the TFA salt. MS(ES+): m/z 381.93 (100)[MH+]. HPLC: tR=2.39 min (Open Lynx polar—5 min).

Provenance & Evidence